The Iroquois and Cherokee were among the first of the American tribes in the eastern United States to use this small perennial plant (Hydrastis canadensis) medicinally. They harvested its fleshy underground stems (rhizomes) and roots and used them to treat a variety of infections and other complaints, from insect bites and digestive upset to eye and skin ailments. By the nineteenth century, healers began to refer to this native wildflower (which resembles a buttercup) as goldenseal because the cuplike scars on its bright yellow rhizomes resembled the wax seals then used to close envelopes and certify documents. The plant’s colorful roots also provided dye for clothing.