{"id":7322,"date":"2015-11-16T05:10:58","date_gmt":"2015-11-16T11:10:58","guid":{"rendered":"https:\/\/wholehealthchicago.com\/?p=7322"},"modified":"2022-03-21T15:26:30","modified_gmt":"2022-03-21T20:26:30","slug":"a-baffling-mystery-treating-pain-and-depression","status":"publish","type":"post","link":"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression","title":{"rendered":"A Baffling Mystery: Treating Pain and Depression"},"content":{"rendered":"\n<p>We definitely treat a lot of patients with chronic pain and chronic depression at WholeHealth Chicago. I could list the potential sources of all this pain, all this <a href=\"https:\/\/wholehealthchicago.com\/blog\/2017\/11\/27\/depression-inflammation-and-you-2\" target=\"_blank\" rel=\"noreferrer noopener\">depression<\/a>, but why bother? If pain or depression melt away your <em>joie de vivre,<\/em> we try to help.<\/p>\n\n\n\n<p>Depending on personal preferences, we offer a <a href=\"https:\/\/wholehealthchicago.com\/about-whc\/\" target=\"_blank\" rel=\"noopener\">variety of treatment combinations<\/a>: prescription medication if needed, along with complementary therapies such as chiropractic, massage, mind-body therapy, acupuncture, Healing Touch, homeopathy, herbs, psychotherapy, and so forth. We\u2019re no fans of the take-a-pill-for-every-ill philosophy so prevalent in medicine today.<\/p>\n\n\n\n<p><a href=\"https:\/\/wholehealthchicago.com\/about\/david-edelberg\/\" target=\"_blank\" rel=\"noopener\">Myself<\/a>, along with Drs.&nbsp;Kelley&nbsp;and Donigan&nbsp;at WholeHealth Chicago are the ones with access to prescription pads, and we all keep abreast of the newer medications as they\u2019re tested, approved by the FDA, and released to the general public. Whether or not an insurer will foot the bill is another issue altogether. These days it seems we need to get prior approval for even the least expensive generics.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Random clinical trials<\/strong><\/h3>\n\n\n\n<p>Like all new drugs, pain meds (called analgesics) and antidepressants are clinically tested by random clinical trials (RCTs), in which a large group of patients with a common condition (such pain or major depressive disorder) are divided into two groups. One group receives the actual drug being tested and the other a placebo, or sugar pill. Even investigators don\u2019t know who gets what.<\/p>\n\n\n\n<p>After a few weeks, patients report what they\u2019ve experienced, and then everybody switches pills, again anonymously, so someone who unknowingly received the placebo now gets the actual med and vice versa. Again, after a few weeks they report the effects: positive (feeling better), negative (side effects), or nothing at all.<\/p>\n\n\n\n<p>The whole process is called a randomized placebo-controlled crossover clinical trial and there are literally thousands of these studies being performed around the world. Generally, they\u2019re subsidized by Big Pharma, mightily praying that its drug is a winner. If so, the FDA gives a thumbs up and the profits pour in.<\/p>\n\n\n\n<p>With some RCTs, though, there\u2019s no financial gain for anyone. These trials mainly test techniques (\u201cDoes acupuncture help back pain?\u201d) or natural products (\u201cDoes ginger help nausea?\u201d) and are supported by medical schools or even by interested physicians.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>A strange turn of events<\/strong><\/h3>\n\n\n\n<p>In recent years, two very interesting phenomena about RCTs have emerged, leaving investigators utterly flummoxed. Ready for this?<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>In RCTs involving both pain medications and antidepressants, the pain\/depression-relieving effect of the placebo is almost the same as the effect of the medications themselves<\/strong>. In other words, patients who are unknowingly receiving sugar pills are reporting good results for pain\/depression relief, while patients receiving the actual pain drug\/antidepressant are reporting good results as well. Hmm\u2026<\/li><li><strong>This strange phenomenon is <a href=\"https:\/\/www.huffingtonpost.com\/entry\/placebo-effect-us-drug-trials-study_561d0208e4b028dd7ea50659?ir=Science%253Fncid%253Dnewsltushpmg00000003\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">occurring exclusively in clinical trials based in the US<\/a><\/strong>. It\u2019s not being observed in foreign clinical drug trials. Double Hmm\u2026<\/li><\/ul>\n\n\n\n<p>When the results of an expensive clinical trial prove a med is no better than the placebo, the FDA denies approval and millions of Big Pharma research dollars (and potentially billions in profits) go down the drain. Thus, trying to figure out what\u2019s happening among American RCTs becomes pretty important. The most educated guesses are just that\u2014guesses, but most investigators think the scenario looks something like the following.<\/p>\n\n\n\n<p>People in the US do take a lot of medication, <a href=\"https:\/\/www.washingtonpost.com\/news\/to-your-health\/wp\/2015\/11\/03\/more-americans-than-ever-are-taking-prescription-drugs\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">more than anyone else on the planet<\/a>. Currently, 59% of people over 20 are taking one or more prescription drugs and 15% are taking <u>five or more<\/u>, a significant increase since 2000 and especially over the last decade.<\/p>\n\n\n\n<p>The increase is attributed to our skyrocketing rates of obesity. Right now, almost 40% of Americans <a href=\"https:\/\/www.cdc.gov\/nchs\/data\/databriefs\/db219.htm\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">are in the clinically obese range<\/a>. Because of this, Americans take more prescription drugs than ever for obesity-related diabetes, high blood pressure, and heart disease.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Unrealistic expectations<\/strong><\/h3>\n\n\n\n<p>Because Americans rely on medications to treat just about everything, we\u2019ve developed unrealistic expectations about anything in pill form. In addition, most of us know at least something about randomized clinical trials. So when we\u2019re told by an authority figure \u201cWe\u2019re testing a new medication for your particular problem,\u201d we sign up to participate, drink the Kool-Aid, and in our hearts believe it\u2019s going to work.<\/p>\n\n\n\n<p>\u201cWell,\u201d we mumble to ourselves, \u201cI\u2019m already taking X pill for Y problem and it works, Z pill for A problem, and it works, so this new pill I\u2019m testing is going to work, too.\u201d And lo! it does.<\/p>\n\n\n\n<p>There are a few very important lessons to learn from this phenomenon:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li><strong>Physicians and patients alike are too reliant on pharmaceuticals to treat ailments<\/strong>. We\u2019ve all been brainwashed, I by my drug rep or reading some biased, self-serving clinical trial published in JAMA and you by the latest TV commercial or unquestioning acceptance of your doctor\u2019s hastily written prescription. Yes, undeniably, you may have pain and, yes, you might feel seriously depressed, but if placebos are proven to relieve these symptoms, then all of us need to think twice before I prescribe and you swallow more pills. We (the entire medical profession) need to consider alternative therapies instead.<\/li><li><strong>Doctors must develop the same belief system in alternative therapies that we currently have in pharmaceuticals<\/strong>. Since physicians are enamored of clinical trials, then let\u2019s run them on alternative therapies, but they must be done correctly. Smoke emerges from my ears when I read a clinical trial proving something like acupuncture doesn\u2019t work when the technique used in the study is blatantly incorrect.<\/li><li><strong>We need to let it sink in that we\u2019re spending billions of dollars on drugs that in many cases are no better than sugar pills<\/strong>.<\/li><li><strong>We\u2019re going to lose if our thinking goes along these lines: \u201cI don\u2019t have time to work with a nutritionist so I\u2019ll just increase my insulin.\u201d<\/strong> \u201cMy insurance won\u2019t cover acupuncture or yoga therapy, so I\u2019ll just take some more Vicodin.\u201d \u201cI don\u2019t have time for counseling, so I\u2019ll increase my Zoloft.\u201d<\/li><\/ol>\n\n\n\n<p>Yikes.<\/p>\n\n\n\n<p>Be well,<br><em>David Edelberg, MD<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We definitely treat a lot of patients with chronic pain and chronic depression at WholeHealth Chicago. I could list the potential sources of all this pain, all this depression, but why bother? If pain or depression melt away your joie de vivre, we try to help. Depending on personal preferences, we offer a variety of [&hellip;]<\/p>\n","protected":false},"author":2087,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23,2,2336,2335,3,34,119],"tags":[520,1338,13,118,1703,192,202,1283,1084,102,1788,1807,1278,146,1426],"class_list":["post-7322","post","type-post","status-publish","format-standard","hentry","category-a","category-blog","category-healing-touch","category-homeopathy","category-knowledge-base","category-mental-health","category-pain-management","tag-alternative-medicine","tag-anti-depressants","tag-big-pharma","tag-chronic-pain","tag-clinical-psychologists","tag-depression","tag-health-insurance","tag-integrative-medicine","tag-lifestyle-medicine","tag-pain","tag-pharmaceuticals","tag-placebo","tag-psychiatric-drugs","tag-psychotherapy","tag-randomized-clinical-trials"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>A Baffling Mystery: Treating Pain and Depression<\/title>\r\n<meta name=\"description\" content=\"We definitely treat a lot of patients with chronic pain and chronic depression at WholeHealth Chicago.\" \/>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression\" \/>\r\n<meta property=\"og:locale\" content=\"en_US\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"A Baffling Mystery: Treating Pain and Depression\" \/>\r\n<meta property=\"og:description\" content=\"We definitely treat a lot of patients with chronic pain and chronic depression at WholeHealth Chicago.\" \/>\r\n<meta property=\"og:url\" content=\"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression\" \/>\r\n<meta property=\"og:site_name\" content=\"WholeHealth Chicago\" \/>\r\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/wholehealthchicago\" \/>\r\n<meta property=\"article:published_time\" content=\"2015-11-16T11:10:58+00:00\" \/>\r\n<meta property=\"article:modified_time\" content=\"2022-03-21T20:26:30+00:00\" \/>\r\n<meta name=\"author\" content=\"wholehealthchicago\" \/>\r\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\r\n<meta name=\"twitter:creator\" content=\"@wholehealthchi\" \/>\r\n<meta name=\"twitter:site\" content=\"@wholehealthchi\" \/>\r\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"wholehealthchicago\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression\",\"url\":\"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression\",\"name\":\"A Baffling Mystery: Treating Pain and Depression\",\"isPartOf\":{\"@id\":\"https:\/\/wholehealthchicago.com\/blog\/#website\"},\"datePublished\":\"2015-11-16T11:10:58+00:00\",\"dateModified\":\"2022-03-21T20:26:30+00:00\",\"author\":{\"@id\":\"https:\/\/wholehealthchicago.com\/blog\/#\/schema\/person\/8f28cef347f94e6801d2bdd38b9cea19\"},\"description\":\"We definitely treat a lot of patients with chronic pain and chronic depression at WholeHealth Chicago.\",\"breadcrumb\":{\"@id\":\"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/wholehealthchicago.com\/blog\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A Baffling Mystery: Treating Pain and Depression\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/wholehealthchicago.com\/blog\/#website\",\"url\":\"https:\/\/wholehealthchicago.com\/blog\/\",\"name\":\"WholeHealth Chicago\",\"description\":\"WholeHealth Chicago is the Midwest&#039;s oldest and most respected center for integrative care, successfully blending the latest advances in conventional medicine with a wide range of clinically proven alternative therapies.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/wholehealthchicago.com\/blog\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/wholehealthchicago.com\/blog\/#\/schema\/person\/8f28cef347f94e6801d2bdd38b9cea19\",\"name\":\"wholehealthchicago\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/wholehealthchicago.com\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/b63bce17acaeb51f185933c60fa6fa86c347679a70b79ec51e5b772e271a469f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/b63bce17acaeb51f185933c60fa6fa86c347679a70b79ec51e5b772e271a469f?s=96&d=mm&r=g\",\"caption\":\"wholehealthchicago\"},\"url\":\"https:\/\/wholehealthchicago.com\/blog\/author\/wholehealthchicago\"}]}<\/script>\r\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A Baffling Mystery: Treating Pain and Depression","description":"We definitely treat a lot of patients with chronic pain and chronic depression at WholeHealth Chicago.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression","og_locale":"en_US","og_type":"article","og_title":"A Baffling Mystery: Treating Pain and Depression","og_description":"We definitely treat a lot of patients with chronic pain and chronic depression at WholeHealth Chicago.","og_url":"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression","og_site_name":"WholeHealth Chicago","article_publisher":"https:\/\/www.facebook.com\/wholehealthchicago","article_published_time":"2015-11-16T11:10:58+00:00","article_modified_time":"2022-03-21T20:26:30+00:00","author":"wholehealthchicago","twitter_card":"summary_large_image","twitter_creator":"@wholehealthchi","twitter_site":"@wholehealthchi","twitter_misc":{"Written by":"wholehealthchicago","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression","url":"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression","name":"A Baffling Mystery: Treating Pain and Depression","isPartOf":{"@id":"https:\/\/wholehealthchicago.com\/blog\/#website"},"datePublished":"2015-11-16T11:10:58+00:00","dateModified":"2022-03-21T20:26:30+00:00","author":{"@id":"https:\/\/wholehealthchicago.com\/blog\/#\/schema\/person\/8f28cef347f94e6801d2bdd38b9cea19"},"description":"We definitely treat a lot of patients with chronic pain and chronic depression at WholeHealth Chicago.","breadcrumb":{"@id":"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/wholehealthchicago.com\/blog\/2015\/11\/16\/a-baffling-mystery-treating-pain-and-depression#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/wholehealthchicago.com\/blog"},{"@type":"ListItem","position":2,"name":"A Baffling Mystery: Treating Pain and Depression"}]},{"@type":"WebSite","@id":"https:\/\/wholehealthchicago.com\/blog\/#website","url":"https:\/\/wholehealthchicago.com\/blog\/","name":"WholeHealth Chicago","description":"WholeHealth Chicago is the Midwest&#039;s oldest and most respected center for integrative care, successfully blending the latest advances in conventional medicine with a wide range of clinically proven alternative therapies.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/wholehealthchicago.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/wholehealthchicago.com\/blog\/#\/schema\/person\/8f28cef347f94e6801d2bdd38b9cea19","name":"wholehealthchicago","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/wholehealthchicago.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/b63bce17acaeb51f185933c60fa6fa86c347679a70b79ec51e5b772e271a469f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/b63bce17acaeb51f185933c60fa6fa86c347679a70b79ec51e5b772e271a469f?s=96&d=mm&r=g","caption":"wholehealthchicago"},"url":"https:\/\/wholehealthchicago.com\/blog\/author\/wholehealthchicago"}]}},"_links":{"self":[{"href":"https:\/\/wholehealthchicago.com\/blog\/wp-json\/wp\/v2\/posts\/7322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wholehealthchicago.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wholehealthchicago.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wholehealthchicago.com\/blog\/wp-json\/wp\/v2\/users\/2087"}],"replies":[{"embeddable":true,"href":"https:\/\/wholehealthchicago.com\/blog\/wp-json\/wp\/v2\/comments?post=7322"}],"version-history":[{"count":3,"href":"https:\/\/wholehealthchicago.com\/blog\/wp-json\/wp\/v2\/posts\/7322\/revisions"}],"predecessor-version":[{"id":28026,"href":"https:\/\/wholehealthchicago.com\/blog\/wp-json\/wp\/v2\/posts\/7322\/revisions\/28026"}],"wp:attachment":[{"href":"https:\/\/wholehealthchicago.com\/blog\/wp-json\/wp\/v2\/media?parent=7322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wholehealthchicago.com\/blog\/wp-json\/wp\/v2\/categories?post=7322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wholehealthchicago.com\/blog\/wp-json\/wp\/v2\/tags?post=7322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}