{"id":31287,"date":"2024-01-15T21:37:48","date_gmt":"2024-01-16T03:37:48","guid":{"rendered":"https:\/\/wholehealthchicago.com\/blog\/?p=31287"},"modified":"2024-01-15T21:47:39","modified_gmt":"2024-01-16T03:47:39","slug":"what-is-low-dose-naltrexone-ldn-and-can-it-help-me-2","status":"publish","type":"post","link":"https:\/\/wholehealthchicago.com\/blog\/2024\/01\/15\/what-is-low-dose-naltrexone-ldn-and-can-it-help-me-2","title":{"rendered":"What is Low-Dose Naltrexone (LDN) and Can It Help Me?"},"content":{"rendered":"\n

Fifteen years ago or so was the first time I wrote about the endlessly fascinating multi-purpose inexpensive Low Dose Naltrexone (LDN). Among the majority of conventional physicians, the \u201cneedle\u201d has moved slightly from \u201cnever heard of it\u201d to \u201cI\u2019ve heard of it but don\u2019t prescribe it.\u201d I guess you could call it a \u2018guarded improvement.\u2019 Still, since tens of thousands of LDN Rxs are written each month, somebody must be prescribing it. Can\u2019t just be we at WholeHealth Chicago.<\/p>\n\n\n\n

 I described LDN as an \u201corphan drug,\u201d meaning that the patent had long expired on the original molecule and it had been generic for years, not owned by any one company. For this reason and unable to recoup their investment, no Big Pharma company was interested in pursuing costly clinical trials that might have proven LDN\u2019s usefulness.<\/p>\n\n\n\n

Naltrexone itself (in a 50 mg capsule, and not 4.5 mg. \u201clow dose\u201d) had been FDA approved for patients addicted to opioid medications. It worked by blocking opioid receptors in the brain. With the opioid crisis still here, it is for this that naltrexone is prescribed.<\/p>\n\n\n\n

But an interesting phenomenon was observed among some patients taking naltrexone. Those with two chronic conditions, Crohn\u2019s Disease and Multiple Sclerosis reported improvement of symptoms. Many, in fact, by taking naltrexone were able to reduce their doses of conventional medications, and some could go off their meds completely.<\/p>\n\n\n\n

There was one interesting sidelight: when the naltrexone was given in lower doses (as low as 1\/10th or even 1\/20th of the usual dose), it actually worked better. Hence: Low Dose Naltrexone which you\u2019ll see everywhere as LDN.<\/p>\n\n\n\n

During the years after I wrote the original Health Tip, the list of conditions that might be helped by LDN has, to put it bluntly, exploded. Although this might change eventually, LDN is not available at your local Walgreen\u2019s or CVS, nor is it covered by your insurance. You must seek out a compounding pharmacist (there are hundreds throughout the U.S.). Here the pharmacist is making the capsules individually for your needs as prescribed by your physician. The price varies, usually about $50-60 a month.<\/p>\n\n\n\n

Harder than finding a pharmacy is finding a physician-prescriber for LDN. Many physicians, especially those employed in the mega-groups like Northwestern or Advocate, have agreed to limit prescribing only to those meds with FDA approval. So, for example, when treating an autoimmune condition like rheumatoid arthritis or ankylosing spondylitis, you\u2019ll receive a \u2018biologic\u2019 like Humira, whose side effect might be a major infection like TB, pneumonia or even death. Whereas, the commonest side effect of LDN (really) is \u201cvivid dreams\u201d<\/a>.<\/p>\n\n\n\n

Also at the time of my original article, I asked gastroenterologists and neurologists if they\u2019d heard about LDN for Crohn\u2019s, ulcerative colitis, multiple sclerosis, fibromyalgia and other chronic conditions. Yes, their patients mentioned it. Did they prescribe it? No.<\/p>\n\n\n\n

Now, years later, reflecting the vast increase in the number of conditions helped LDN, we can add allergists, dermatologists, rheumatologists, psychiatrists, pain management specialists, endocrinologists, cancer specialists, kidney specialists, pulmonologists (lung), and infectious disease specialists. This link opens to a non-profit LDN Research Trust and lists all the conditions for which LDN has been prescribed. <\/a><\/p>\n\n\n\n

Is LDN 100% effective for this startling catalog of human (and pet) ailments? Of course not. If this were the case, health care would grind to a halt and everyone would be taking LDN for everything. <\/p>\n\n\n\n

However, this list is meant to show that at least trying 2-3 months of LDN might be an important addition to your current treatment regimen.<\/p>\n\n\n\n

Okay. How does LDN actually work?<\/p>\n\n\n\n

As I said earlier, the regularly dosed naltrexone, the 50 mg. size, simply blocks those landing sites in the brain and nervous system called \u2018opioid receptors.\u2019 The most widely prescribed opioids include medications like Vicodin, Norco, Oxycontin, and morphine. Naltrexone acts as an \u2018antagonist,\u2019 stopping opioid effects. Low dose naltrexone is incapable of blocking opioids and, in fact, is well recognized to be an excellent choice for chronic pain management by the mechanism which I describe later. It is totally non addicting (not being an opioid) and has minimal side effects (those \u2018vivid dreams\u2019 have been mentioned by a third of patients).<\/p>\n\n\n\n

How it works for chronic pain gives us physicians some idea of how LDN works for other conditions. <\/p>\n\n\n\n

First, you need to understand that you\u2019re really taking a mixture of two forms of LDN in every capsule, a levo form, where the molecule is twisted to the left, and a dextro form, twisted to the right. These two forms are called \u2018isomers\u2019 of the molecule. <\/p>\n\n\n\n

The \u2018levo\u2019 form acts to block the opioid receptors. In the process, it also raises the brain\u2019s level of neurotransmitters, especially dopamine, one of the so-called \u201chappy molecules\u201d which explains it\u2019s recent increase among psychiatrists for treatment resistant depression. Raising endorphins also reduces inflammation and in turn reduces pain and improves overall sense of well being<\/p>\n\n\n\n

The \u2018dextro\u2019 form of LDN is more useful for autoimmune diseases, antagonizing cytokine modulated immune cells. \u2018Cytokines\u201d is a very general term for a type of protein released by white cells that either lessens or increases inflammation. A balance of both pro- and anti-inflammatory cytokines is best. An excess of inflammatory cytokines spells trouble. Here\u2019s one study showing how LDN reduced the cytokine inflammation (and the pain) of fibromyalgia<\/a>. Here\u2019s another study that was started last year when it was realized the COVID\u2019s attack on the body was one massive cytokine storm. And (trying desperately not to bore you with this), inflammatory cytokines also damage mitochondria, the energy center within each and every cell. The results of mitochondrial damage are \u201cfatigue,\u201d \u201cmuscle pain,\u201d and \u201cbrain fog.\u201d\u00a0<\/p>\n\n\n\n

So that not by coincidence, the symptoms of fibromyalgia and the symptoms of long COVID are pretty much the same with this important difference: long COVID<\/a> does clear up after about 3-4 months and fibro can last for years. <\/p>\n\n\n\n

If you have just about any chronic condition, it\u2019s worth learning if LDN can be a useful adjunct to your treatment. A quick way to do this is to type the name of your condition (or symptom alone if you don\u2019t have an \u2018official\u2019 diagnosis) into your Google bar along with either \u2018low dose naltrexone\u2019 or LDN. Just now I did this with \u2018psoriasis\u2019 and came up with several quality research articles. Get the drift?<\/p>\n\n\n\n

You can ask your primary care doc or your specialist for an LDN prescription but don\u2019t expect glowing enthusiasm. Expect instead a lecture about \u201coff label drugs,\u201d \u201cunproven,\u201d and ending with \u201cjust take what I tell you to take.\u201d<\/p>\n\n\n\n

However, if you want to pursue a course of LDN, schedule a WholeHealth Chicago appointment, either in-person or telemed, with any of fifteen practitioners<\/a>. All of us are familiar with the benefits of LDN. Virtually all compounders are preparing thousands of prescriptions LDN around the U.S. (and worldwide) so if you have a favorite pharmacist, we\u2019ll be happy to send it there.<\/p>\n\n\n\n

Be well,
David Edelberg, MD<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Fifteen years ago or so was the first time I wrote about the endlessly fascinating multi-purpose inexpensive Low Dose Naltrexone (LDN). Among the majority of conventional physicians, the \u201cneedle\u201d has moved slightly from \u201cnever heard of it\u201d to \u201cI\u2019ve heard of it but don\u2019t prescribe it.\u201d I guess you could call it a \u2018guarded improvement.\u2019 […]<\/p>\n","protected":false},"author":4902,"featured_media":25369,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,209,296,130,3,119,2318,48],"tags":[118,2232,816,1234,2233,102],"class_list":["post-31287","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-fibromyalgia-chronic-fatigue","category-inflammation","category-integrative-medicine","category-knowledge-base","category-pain-management","category-tot-21-blogs-of-21","category-w","tag-chronic-pain","tag-cytokine","tag-inflammation","tag-ldn","tag-low-dose-naltrexone","tag-pain"],"yoast_head":"\r\nWhat is Low-Dose Naltrexone (LDN) and Can It Help Me?<\/title>\r\n<meta name=\"description\" content=\"Ten years ago April marks the anniversary of the first time I wrote about low-dose naltrexone (LDN). 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