{"id":28763,"date":"2021-09-12T17:36:40","date_gmt":"2021-09-12T22:36:40","guid":{"rendered":"https:\/\/wholehealthchicago.com\/blog\/?p=28763"},"modified":"2022-11-14T13:48:34","modified_gmt":"2022-11-14T19:48:34","slug":"chronic-fatigue-myalgic-encephalomyelitis-fibro-and-covid-19","status":"publish","type":"post","link":"https:\/\/wholehealthchicago.com\/blog\/2021\/09\/12\/chronic-fatigue-myalgic-encephalomyelitis-fibro-and-covid-19","title":{"rendered":"Chronic Fatigue\/Myalgic Encephalomyelitis\/Fibro and Covid-19"},"content":{"rendered":"\n<p>Regular readers of British mystery novels from the 1930s and 1940s are familiar with the old trick where the detective actually turns out to be the murderer. Or where Character A, innocent and charming, is none other than Character B, the poisoner.<\/p>\n\n\n\n<p>In other words, the villain can be highly elusive, and every once in a while, occasionally on the last page, the bad guy escapes, only to re-appear in the next novel, dagger (or poison or silk scarf) in hand, ready for more mayhem.<\/p>\n\n\n\n<p>Chronic fatigue, myalgic encephalomyelitis, and fibromyalgia are shape shifters, a bit like the characters in these mysteries, but more and more evidence has been accumulating over the years that all three are variations of the same condition. Fibromyalgia patients present with more pain but certainly have plenty of fatigue. Chronic fatigue-myalgic encephalomyelitis patients can be bedridden with exhaustion, but ask them if their muscles hurt, and they\u2019ll say \u201cOMG, yes!\u201d<\/p>\n\n\n\n<p>Doctors first reported in the 1930s what later became known as <a href=\"https:\/\/wholehealthchicago.com\/blog\/2020\/02\/10\/breakthroughs-in-chronic-fatigue-syndrome\" target=\"_blank\" rel=\"noreferrer noopener\">chronic fatigue syndrome (CFS)<\/a>, but it wasn\u2019t until 1986 that the symptom of utter exhaustion following a severe viral \u00a0illness was recognized by medicine (even as many continued to call the condition Yuppie Flu).<\/p>\n\n\n\n<p>Back in the mid-80s, the villain aux choix was infectious mononucleosis (mono), but test results were inconsistent. Some CFS patients had had terrible cases of mono while other mono patients had no CFS. Still other people had high levels of mono antibodies in their blood but no CFS.<\/p>\n\n\n\n<p>Maybe the fatigued person\u2019s bout with mono had damaged her immune system, weakening her body\u2019s ability to attack other infections due to reduced <a href=\"https:\/\/en.wikipedia.org\/wiki\/Natural_killer_cell\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">NK cell function<\/a>. This concept is <a href=\"https:\/\/www.youtube.com\/watch?v=tuaaEocrusg\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">discussed in the documentary \u201cUnrest<\/a>\u201d (available <a href=\"https:\/\/www.netflix.com\/title\/80168300\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">on Netflix<\/a> and excellent, but painful to watch).<\/p>\n\n\n\n<p>Between then and now, more and more patients were reporting disabling exhaustion to their primary care physicians. Referrals to specialists of all stripes revealed nothing much and often triggered curt dismissals. Many CFS patients were written off as needing psychiatric support or as seeking financial gain from their disability.<\/p>\n\n\n\n<p>Sometimes CFS sufferers actually had neither fibromyalgia nor CFS-myalgic encephalomyelitis (ME), but rather other conditions that mimic CFS\/ME but had been overlooked. For example, for a patient who is sensitive to mold off-gassing toxins, removing the mold from her home can work wonders for her energy. Some fortunate patients have their energy improved with a dietary change, like eliminating gluten, or having an accumulation of lead or mercury removed from their body or getting treated for chronic Lyme disease.<\/p>\n\n\n\n<p>US and European physicians, usually in independent and smaller functional medicine practices like WholeHealth Chicago, are familiar with the diagnostic possibilities and \u00a0\u00a0know how to test for them. Based on the clinical situation, most functional medicine clinicians are willing to consider treatment with intravenous therapies such as vitamins, glutathione, ultraviolet, and ozone, though also with antibiotics, antivirals, and off-label prescription meds like <a href=\"https:\/\/translational-medicine.biomedcentral.com\/track\/pdf\/10.1186\/s12967-021-02721-9.pdf\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Ariprazole <\/a>and Modafinil.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><meta charset=\"utf-8\"><strong>Shape shifter<\/strong><\/h3>\n\n\n\n<p>The fact is that chronic fatigue syndrome\/myalgic encephalomyelitis\/fibromyalgia (CFS\/ME\/fibro) is a true shape shifter with no consistently accurate diagnostic test. A diagnosis is based mainly on your symptom diary and negative diagnostic tests\u2014those that rule out other likely diagnoses.<\/p>\n\n\n\n<p>You\u2019re not anemic, not hypothyroid, you have no autoimmune disease, etc. But your diary tells a clear story: Yes, Monday, you\u2019re tired, but you can go grocery shopping. But Tuesday you\u2019re so exhausted you can\u2019t get out of bed. Wednesday you feel well enough to watch some TV. But by Thursday you can\u2019t &nbsp;&nbsp;&nbsp;follow what\u2019s happening on Real Housewives because your brain isn\u2019t working.<\/p>\n\n\n\n<p>It\u2019s a mouthful, but the term myalgic encephalomyelitis (ME) may describe this elusive condition best: Myalgic means pain in the muscles. &nbsp;Encephalomyelitis is smoldering inflammation in the brain and spinal cord.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><meta charset=\"utf-8\"><strong>What we know<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>70% of cases occur in girls and women, likely because of female susceptibility to autoimmune disease, despite the fact that no tests are positive for autoimmune disease. This is theory.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Most cases follow a viral infection.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>All symptoms worsen after any activity.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>One in four patients with ME\/CFS\/fibro becomes bedridden or housebound .<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>The average age of onset is 40 to 60, but the condition can start at any age.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>1.0 to 2.5 million Americans have ME\/CFS\/fibro.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>90% of people with ME\/CFS\/fibro have not been diagnosed.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>If diagnosed, they\u2019ve not undergone adequate screening to rule out reversible causes of fatigue (e.g., Lyme, toxic mold, mercury).<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Most medical school training programs have no specific guidelines for ME\/CFS\/fibro and patients are often shocked at how little their physicians know about this condition (this is pathetic).<\/li><\/ul>\n\n\n\n<p>Although there\u2019s no single test to diagnose CFS\/ME\/fibro, it was discovered some years ago that patients with both fibromyalgia and CFS have low levels of cytokines circulating in their blood. Cytokines are good guys when it comes to fighting infections, but if the body is swamped by an infection, which can happen with Covid-19, a cytokine storm damages tissue everywhere.<\/p>\n\n\n\n<p>With fibro patients, there is a shortage of cytokines, and this shortage can be measured with a test called FM\/a. <a href=\"https:\/\/www.fmtest.com\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">You can read about this test here<\/a>. Among the many (many!) patients I\u2019ve ordered the test for, I\u2019ve found it clinically very accurate. The FM\/a is as close as we\u2019ve got to a blood test for ME\/CFS\/fibro, though the test is expensive and needs to be cleared by your insurer.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><meta charset=\"utf-8\"><strong>Recovery<\/strong><\/h3>\n\n\n\n<p>Do people recover from ME\/CFS\/fibro? After working with some patients for more than twenty years, the answer seems to be that they can get guardedly better, but never 100%.<\/p>\n\n\n\n<p>After the first crash, patients are usually down for the count for a year, slowly making their way back, and after three to four years are back to 80-90% of their pre-illness function level. But this requires work on their part: gentle exercise, healthful eating, social contacts, optimism.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><meta charset=\"utf-8\"><strong>The covid connection<\/strong><\/h3>\n\n\n\n<p>Let me end with this. If any of you are still unvaccinated, know that at last week\u2019s meeting of the European Respiratory Society, fully 85% of the 239 patients being followed for Covid long-haul symptoms reported chronic fatigue as their #1 symptom.<\/p>\n\n\n\n<p>At that same meeting, physicians from the Aga Khan Hospital in Karachi reported treating 65 patients with &nbsp;&nbsp;Ivermectin and 67 with steroids and the results were equally poor. Ivermectin scored another flop. Please, no more calls for Ivermectin.<\/p>\n\n\n\n<p>You might also want to read <a href=\"https:\/\/www.hopkinsmedicine.org\/news\/newsroom\/news-releases\/covid-19-news-for-many-long-covid-looks-a-lot-like-chronic-fatigue\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">this provocative piece<\/a> on long covid and CFS from Johns Hopkins.<\/p>\n\n\n\n<p>And lastly, a team of rheumatologists from Italy, which was especially hard hit by Covid-19, concluded based on survey material that one third of long-haul Covid-19 patients developed classical fibromyalgia, which they dubbed FibroCovid. These were mainly people who got infected pre-vaccine and, most interesting, the majority of cases were among men.<\/p>\n\n\n\n<p>Please get vaccinated, and be well,<\/p>\n\n\n\n<p>David Edelberg, MD<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Regular readers of British mystery novels from the 1930s and 1940s are familiar with the old trick where the detective actually turns out to be the murderer. Or where Character A, innocent and charming, is none other than Character B, the poisoner. In other words, the villain can be highly elusive, and every once in [&hellip;]<\/p>\n","protected":false},"author":2087,"featured_media":28766,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2269,195,209,2333,2318],"tags":[343,2150,208,2007],"class_list":["post-28763","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid","category-diseases","category-fibromyalgia-chronic-fatigue","category-functional-medicine","category-tot-21-blogs-of-21","tag-chronic-fatigue","tag-covid-19","tag-fibromyalgia","tag-myalgic-encephalomyelitis"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Chronic Fatigue\/Myalgic Encephalomyelitis\/Fibro and Covid-19<\/title>\r\n<meta name=\"description\" content=\"Chronic fatigue, myalgic encephalomyelitis, and fibromyalgia are shape shifters, a bit 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