{"id":12905,"date":"2018-11-11T19:11:42","date_gmt":"2018-11-12T01:11:42","guid":{"rendered":"https:\/\/wholehealthchicago.com\/?p=12905"},"modified":"2022-03-21T15:10:03","modified_gmt":"2022-03-21T20:10:03","slug":"how-to-get-off-statins-2","status":"publish","type":"post","link":"https:\/\/wholehealthchicago.com\/blog\/2018\/11\/11\/how-to-get-off-statins-2","title":{"rendered":"How To Get Off Statins"},"content":{"rendered":"\n<p class=\"entry-title post-title\">Getting off <a href=\"https:\/\/wholehealthchicago.com\/blog\/2016\/10\/10\/making-easier-say-no-statins\" target=\"_blank\" rel=\"noreferrer noopener\">statins <\/a>is easy. Stop swallowing the pill. If you\u2019re not in a potentially high-risk group (as described below) and your doc prescribed a statin to get your cholesterol down a bit, you won\u2019t have a heart attack or a stroke that day or week or probably that decade.<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code><div class=\"post-entry\">\n<p>There\u2019s no \u201cstatin withdrawal\u201d and you weren\u2019t born with a statin deficiency.<\/p>\n<p>In fact, many of you quitting statins will probably start feeling better in just a couple weeks. I admit \u201cbetter\u201d is rather vague, but perhaps you\u2019re so used to having achy muscles, fatigue, and brain fog that you think these symptoms are normal.<\/p>\n<p>Does my recommendation to stop taking your statin sound glib, a bit cavalier? After all, when you were handed the prescription you were told something like \u201cYou must take this every day or you\u2019ll get a stroke or heart attack.\u201d And now I come along suggesting that for most of you statins are simply not necessary\u2026provided you\u2019re willing to take charge of your health.<\/p>\n<p><strong>A new verb: deprescribing<\/strong>\nThe statin controversy is quite lively among physicians themselves. John Mandrola, MD, a cardiac electrophysiologist from Louisville, wrote a short blog post on the physician-only portion of Medscape expressing his doubts about statins. You can\u2019t link to his piece without a password, but do have a look at Dr. Mandrola\u2019s very good website and especially at this piece, \u201c<a href=\"https:\/\/www.drjohnm.org\/2014\/10\/to-deprescribe-adding-a-new-verb-to-the-language-of-doctoring\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">To Deprescribe\u2026Adding a New Verb to the Language of Doctoring<\/a>.\u201d<\/p>\n<p>Dr. Mandrola\u2019s Medscape post received an astonishing 631 physician comments, most of which supported his position, namely that the 2014 guidelines from the American College of Cardiology (ACC) on statin prescribing were not only unrealistic, but potentially dangerous.\u00a0\u00a0<span class=\"s1\">In addition,<\/span><a href=\"https:\/\/www.mdedge.com\/ecardiologynews\/article\/138907\/preventive-care\/statins-no-benefit-primary-prevention-elderly\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"><span class=\"s2\"> this JAMA study published in 2017<\/span><\/a><span class=\"s2\"> found that\u00a0statins are of\u00a0virtually\u00a0no benefit as a primary prevention of heart disease in people 65 and older.\n<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Of course, all this came out after all the statins went generic and Big Pharma had generated hundreds of billions of dollars in revenue. Statins have been the biggest moneymaker in the history of medicine.<\/span><\/p>\n<p>There are four guidelines regarding who should take statins. Many physicians in the US and most in Europe agree with the first two, partially with the third, and not at all with the fourth (my comments in italics):<\/p>\n<ol>\n<li><strong>People 40 to 70 with Type 1 or 2 diabetes.<\/strong>\u00a0This group has an increased risk for heart disease, including heart attack, and taking statins has been shown to reduce this risk. (<em>However, diabetes is a potentially reversible condition with weight loss and exercise, and once the diabetes has been reversed it is possible to go off statins.<\/em>)<em>\u00a0<\/em><\/li>\n<li><strong>People with a history of a cardiovascular \u201cevent\u201d<\/strong>\u00a0such as heart attack, stroke, transient ischemic attack (TIA), angina, or peripheral artery disease (<em>statins definitely reduce the chances for a second such event<\/em>).<\/li>\n<li><strong>People 21 or older with a very high level of bad cholesterol<\/strong>\u2013LDL 190 mg\/dl or higher. (<em>Even though the high cholesterol may be genetic rather than lifestyle-induced, you needn\u2019t capitulate entirely to your genes. Healthful eating, weight reduction, and exercise can bring down high cholesterol of any kind, including genetic. If, after several months of lifestyle changes, your cholesterol remains stuck in a danger zone, then taking a statin is reasonable, especially if along with genetic high cholesterol you also have a genetic premature early death risk.<\/em>)<\/li>\n<li><strong>People 40 to 75 with no cardiovascular disease, a (bad cholesterol) LDL of 70 mg\/dl or higher, and who have a 7.5% or greater risk of having a heart attack or stroke within 10 years<\/strong>\u00a0(<em>the 7.5% or higher is predicated primarily on reversible \u00a0lifestyle factors\u2014see more below<\/em>).<\/li>\n<\/ol>\n<p>Note: the ACC does acknowledge that beyond age 75, there is no significant data showing any heart disease prevention benefit from statins.<\/p>\n<p><strong>Lifestyle\u2026again<\/strong>\nIt\u2019s Number 4 that caused a great deal of eyebrow raising among doctors. The risk factors that would put a person in the 7.5% category include genetic susceptibility, yes, but also smoking, obesity (especially belly fat), inactivity, high blood pressure, and a significant family history of early heart disease. When these factors are combined with the newly established LDL of 70 mg\/dL, it\u2019s estimated that in the US alone the number of current statin users would increase from 12.8 million to 48 million.<\/p>\n<p>If you\u2019ve been following the news on bad cholesterol over the years, it used to be worrisome when LDL was higher than 100 mg\/dL. According to the ACC guidelines, 36 million more people now need statins to hit that glorious 70 mg\/dL. That means one adult in three would be taking statins, as many as one billion statin users worldwide, and total statin sales at $1 trillion a year.<\/p>\n<p>But wait a minute. Except for the genetic susceptibility to early heart disease, every one of those factors that would place someone in the 7.5% risk group is reversible with lifestyle modification. And, most importantly, lifestyle changes will help even if you\u2019re genetically predisposed to heart disease. Also, the newly available Corus-CAD test (which I\u00a0discussed in a previous Health Tip) can confirm or refute your personal genetic susceptibility. If you\u2019re concerned about your susceptibility to heart disease, I do suggest the Corus-CAD.\u00a0 It might be a good idea to get this test if you\u2019re in that LDL group with 190 mg\/dL or higher.<\/p>\n<p>With all this in mind, read these aloud.<\/p>\n<ul>\n<li><strong>Lifestyle beats statins every time<\/strong>. A healthy lifestyle is the foundation of cardiovascular health, period. There has never been a study undertaken to prove that statins are superior to lifestyle changes, and you can probably guess why: lifestyle would win hands down.<\/li>\n<li><strong>Preventable heart attacks<\/strong>. A recent Swedish study proved that four out of five heart attacks in men were completely preventable. When 20,721 men agreed to stop smoking, eat healthfully, lose weight (<a href=\"https:\/\/www.nih.gov\/news\/health\/apr2008\/niddk-07.htm\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">belly fat<\/a>, people), and reduce alcohol, after ten years there was an 86% reduction in the number of expected heart attacks for that number of men.<\/li>\n<li><strong>False reassurance.\u00a0<\/strong>Recent studies also show\u00a0<a href=\"https:\/\/www.medscape.com\/viewarticle\/824093\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">people who take statins eat more, move less, and gain weight<\/a>, thus increasing their heart disease risks and cancelling any already dubious benefit they think they\u2019re receiving. People who take statins are falsely reassured (in the well-chosen words of\u00a0<em>JAMA: Internal Medicine<\/em>\u00a0editor Rita Redberg, MD) that they\u2019re getting some protection.<\/li>\n<\/ul>\n<p><strong>Statin side effects<\/strong>\nStatins work by blocking an enzyme called HMG-CoA reductase, which controls cholesterol production in the liver. However, this enzyme is also responsible for your body\u2019s production of coenzyme Q-10, a powerful antioxidant that prevents age-related macular degeneration, heart disease, and fatigue. The muscle pain caused by statins (the pharmaceutical industry reports this at 2%, primary care physicians at 30%) occurs as the statin lowers your CoQ10 levels.<\/p>\n<p>As a side note, everyone (and I do mean everyone) taking statins should also be taking CoQ10 (<a href=\"https:\/\/whcstore.vitogenix.com\/s\/search?q=100%20mg%20UBQH\" target=\"_blank\" rel=\"noreferrer noopener\">100 mg UBQH<\/a>\u00a0daily).<\/p>\n<p>Statin use has also been associated with memory impairment (25% of your body\u2019s cholesterol is in your brain) and with the early onset of cataracts (27% increased risk among statin users).<\/p>\n<p>One reason statins are a no-no in older adults is that\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18757771\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">a 2008 NIH study<\/a>\u00a0showed that after age 70, best memory function was observed in those with highest cholesterol levels.<\/p>\n<p><strong>Back to Dr Mandrola<\/strong>\nAmong the 631 physician comments that Dr. Mandrola received on his blog, several pointed out that doctors virtually had to prescribe statins because they couldn\u2019t offer their patients nutritionists and exercise equipment (or, I would add, prescribe it with the expectation the patient would be reimbursed) and that many patients simply were so chronically noncompliant with health care advice that the doctor was lucky if she could get them to take the statin itself.<\/p>\n<p>Dr Mandrola was sympathetic, but felt an attitude change among physicians was in order.<\/p>\n<p>Sidebar: WholeHealth Chicago has three nutritionists and although most WHC patients work out regularly, I do maintain for my patients a list of personal fitness trainers.<\/p>\n<p>Physicians at the blog also asked about other cholesterol-lowering agents (such as prescription niacin, called Niaspan, and Zetia, which works by blocking cholesterol being absorbed from the digestive tract) and supplements (red yeast rice, plant sterols). Again, however, taking pills misses the point. All of these do lower cholesterol, though not as dramatically as statins, but none is superior to lifestyle modifications for overall heart disease prevention.<\/p>\n<p>In the 19 years since WholeHealth Chicago opened, I\u2019m aware of exactly two patients who died of a heart attack, and both were at high risk when they arrived. I attribute this really low number to the majority of our patients being highly motivated to live lives of wellness. They accomplish this via healthful eating (guided by our nutritionists if needed), weight reduction, and regular exercise. I can\u2019t think of a single patient who\u2019s still smoking.<\/p>\n<p>Patients who resist the sort of DIY efforts we endorse seem to just drift away to pill-pushing medical practices where physicians are agreeable golden retrievers in comparison to our own WHC wellness wolverines.<\/p>\n<p><strong>Statin summary<\/strong>\nReturn to the four reasons for statins listed above.<\/p>\n<ul>\n<li><strong>If you\u2019re in groups 1 or 2 (you have Type 1 or 2 diabetes or you\u2019ve had a previous cardiovascular event), stay on your statin.<\/strong>\u00a0If you\u2019re mildly diabetic, know it\u2019s reversible and being statin-free is a possibility.<\/li>\n\n<li><strong>If you\u2019re in the third group (LDL over 190 mg\/dL), meet with a nutritionist, start eating well and working out, and get further testing, especially the Corus CAD<\/strong>. You\u2019ll probably be able to stop your statin in a few months.<\/li>\n\n<li><strong>Members of the fourth group are likely taking statins unnecessarily.<\/strong>\u00a0You may be thinking it\u2019s helping when it\u2019s really not. Stop your statin, review the discussion of lifestyle factors above, and get to work on yourself. If you simply cannot commit to significant lifestyle changes, then you might as well CYA and go back on the statin. Just don\u2019t expect it to perform miracles.<\/li>\n<\/ul>\n\n\n<p>Be well,\n<em>David Edelberg, MD<\/em><\/p>\n<\/div><\/code><\/pre>\n","protected":false},"excerpt":{"rendered":"<p>Getting off statins is easy. Stop swallowing the pill. If you\u2019re not in a potentially high-risk group (as described below) and your doc prescribed a statin to get your cholesterol down a bit, you won\u2019t have a heart attack or a stroke that day or week or probably that decade.<\/p>\n","protected":false},"author":2087,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[352,28,214,2,139,398,67,50,296,130,2331,3,34,43,2332],"tags":[],"class_list":["post-12905","post","type-post","status-publish","format-standard","hentry","category-aging","category-alternative-therapies","category-big-pharma-evils","category-blog","category-cardiovascular-health","category-fitness-exercise","category-h","category-healthy-lifestyle","category-inflammation","category-integrative-medicine","category-internal-medicine","category-knowledge-base","category-mental-health","category-nutrition-nutritional-supplements-vitamins-herbal-remedies","category-preventive-medicine"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>How To Get Off Statins | WholeHealth Chicago<\/title>\r\n<meta 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