2265 North Clybourn Avenue    Chicago, IL 60614    P: 773.296.6700     F: 773.296.1131

NADH (Nicotinamide adenine dinucleotide)

What Is It?

Nicotinamide adenine dinucleotide, or NADH, is a coenzyme made from Vitamin B3, or niacin. It’s present in all living cells. As a coenzyme, NADH serves an important role in helping enzymes to function as they should. (An Enzyme is a Protein that works like a catalyst in the body to prompt chemical changes in other substances; breaking down food into energy is an example.) Most coenzymes are synthesized from vitamins, and for optimal energy production, the body needs good amounts of them. The coenzyme, NADH, is no exception.

In people, NADH stimulates the production of ATP (adenosine triphosphate), a compound that regulates the release of energy stored in cells. The more NADH a cell has, the more chemical energy it produces.

Research findings indicate that increased concentrations of NADH in the brain may boost the production of neurotransmitters brain chemicals vital to sound mental function.

Until recently, NADH could only be given intravenously because stomach acid would rapidly destroy the delicate molecule. But a new enteric-coated, oral tablet containing NADH is now available.

Health Benefits

Oral NADH supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia. Researchers are also studying the value of NADH supplements for improving mental function in people with Alzheimer’s disease, and minimizing physical disability and relieving depression in people with Parkinson’s disease.

Some healthy individuals also take NADH supplements orally to improve concentration and memory capacity, as well as to increase athletic endurance. However, to date there have been no published studies to indicate that using NADH is in any way effective or safe for these purposes.

Specifically, NADH may help to:

  • Relieve chronic fatigue syndrome. A recent study supported by the Food and Drug Administration found that the oral form of NADH helped a small group of patients with chronic fatigue syndrome. In the study, 31% of the participants said they felt more vigorous and mentally alert when taking daily NADH. Only 8% of those taking the Placebo reported such improvements.

 

  • Lift general fatigue as well as fibromyalgia-related exhaustion. Because NADH increases energy in cells, some researchers speculate that it may also boost energy in people with fibromyalgia, a disorder characterized by muscle pain and fatigue. NADH may also keep simple, daily fatigue at bay by helping to supply muscle cells with energy.
  • Relieve depression. Imbalances in brain chemicals are a primary cause of certain types of depression. Because NADH stimulates the production of many key chemicals called neurotransmitters, it may have a role to play in relieving the symptoms of depression. No clinical trials to demonstrate this effect have been conducted so far, however.
  • Complement Parkinson’s therapy. There is early evidence that NADH supplements may raise levels of dopamine, a compound crucial to slowing the physical symptoms of Parkinson’s disease and relieving the depression that often accompanies them. (People with Parkinson’s disease have dwindling supplies of dopamine.)
  • Improve Alzheimer’s symptoms. Some European studies of NADH have shown promise for treating people with Alzheimer’s disease, but as of yet, no well-designed double-blind, placebo-controlled trials have been conducted to demonstrate this effect. One preliminary study did show that cognitive dysfunction improved in a very small group of Alzheimer’s patients taking NADH.

Forms

  • tablet

Dosage Information

Special Tips:

–To reduce the risk of side effects, such as jitteriness and mild overstimulation, start out with a small oral dose (2.5 mg a day) for a couple of weeks, gradually increasing the dose over a period of two to three weeks.

  • For chronic fatigue syndrome, 2.5 mg twice a day for 10 days or one package, then 5 mg twice a day
  • For fatigue, 2.5 mg twice a day for 10 days or one package, then 5 mg twice a day
  • For fibromyalgia, 2.5 mg twice a day for 14 days (or one package, see label), then 5 mg twice a day
  • For Parkinson’s disease, 5 mg a day, gradually increasing over two weeks to 10 mg twice a day.

 

  • For Alzheimer’s disease, 5 mg twice a day

Guidelines for Use

Take NADH with water on an empty stomach.

General Interaction

There are no known drug or nutrient interactions associated with NADH in oral or injectable form, although more research is needed.

Possible Side Effects

High doses of NADH (10 mg a day or more) may cause jitteriness, anxiety, and insomnia.

Cautions

The safety of long-term treatment with oral NADH remains unclear. Most sources recommend using it for periods of no more than four months, then taking a month off before starting again. An alternative is to take it only two or three times a week, rather than daily.

Ailments

Alzheimer’s Disease – 5 mg twice a day

Chronic Fatigue Syndrome – 2.5 mg twice a day for 10 days or one package, then 5 mg

twice a day

Fatigue – 2.5 mg twice a day for 10 days or one package, then 5 mg twice a day

Fibromyalgia – 2.5 mg twice a day for 14 days (or one package, see label), then 5 mg twice a day

Parkinson’s Disease – 5 mg a day, gradually increasing over two weeks to 10 mg twice a day

For product recommendations and orders click here for the Natural Apothecary or call 773-296-6700, ext. 2001.

Leave a Comment


  1. Maria DiSebastiano says:

    Where does NADH ( Reduced ß – Nicotinamide Adenine Dinucleotide)come from that is used in the pill form? Are they live cells? If so, where are they taken from? Plants or animals?

  2. Dr E says:

    Hi Maria
    It is manufactured from niacin and is synthetic. Not animal sourced

  3. LJ Jackson says:

    These doses are about 1/8 the amount given on the bottle, and other websites. They are at 125 mg / day. Which do you feel is more useful for fibromyalgia or chronic fatigue?

Join our Newsletter

Get health recommendations, delicious and time-saving recipes, medical news, supplement reviews, birthday discounts, and more!

BIRTHDAY

Health Tips

Dr. Edelberg’s Health Tips contain concise bits of advice, medical news, nutritional supplement and pharmaceutical updates, and stress relief ideas. With every Health Tip, you’ll also receive an easy, delicious, and healthful recipe.

When you sign up to receive Health Tips, you can look forward to Dr. Edelberg’s smart and very current observations arriving in your in-box weekly. They’re packed with helpful information and are often slightly irreverent. One of the most common responses to the tips is “I wish my doctor talked to me like this!”

Quick Connect

Get One Click Access to our

patient-portal

The Knowledge Base

Patient education is an integral part of our practice. Here you will find a comprehensive collection of staff articles, descriptions of therapies and nutritional supplements, information addressing your health concerns, and the latest research on nutritional supplements and alternative therapies.

Join our Newsletter

Get health recommendations, recipes, medical news, supplement reviews, birthday discounts, and more!

Upcoming Workshops

**Pain Relief with Myofascial Balls
Tuesday, October 29, 6-8pm
With Renee Zambo, C-IAYT Yoga Therapist

Course Fee: $65.00
(includes WholeHealth Chicago Myofascial Release Kit, $40 value)

Does that same spot in your neck, shoulders, back or hips seem to bother you every day? Do you have joint aches and pains in the hands and feet? Would you like to learn ways to alleviate that pain and tension?

Join WholeHealth Chicago’s Yoga and Movement Therapist Renee Zambo for an evening of muscle tension release with myofascial therapy balls.

Space is limited and registration is required.
Please register online.
Call the Center for additional information at (773) 296-6700
More>>

Recent Health Tips

  • Dandruff, Fungi, and Cancer of the Pancreas

    It’s an eye-catching title, I’ll admit. But the links are quite real and further research may guide medicine in new directions of cancer prevention and treatment. It all starts in your gut microbiome, the totality of microorganisms–bacteria, viruses, protozoa, and fungi–present in your gastrointestinal (GI) tract, mouth to anus. Until recently, researchers and clinical physicians alike paid virtually no attention to the microbiome and the Read More

  • New Hope For Sinus Sufferers

    When osteopath Dr. Rob Ivker moved to Colorado in the 1980s to set up his family practice, he had no idea that when he stepped off the plane he’d succumb to symptoms of chronic sinusitis that just wouldn’t go away: stuffy nose, thick mucus, pressure behind his cheekbones and above his eyebrows, dull aching headache, and thick goopy drainage in the back of his throat. Read More

  • Director of IV Therapies Katie McManigal, BSN, ANP

    Most people at some point in their lives have had an intravenous (IV) line. An adept nurse warned you about the tiny pinch of the needle as it was smoothly inserted and taped in place.  Then the  fluid dangling above your head slowly started making its way through a tube and into your body. IVs are all over the place in hospitals. They’re seen in Read More

October Sale – Save 20% off UltraMeal Rice

UltraMeal RICE is a tasty, non-dairy, nutritionally fortified, powdered meal replacement for those who want to support healthy body composition but may be sensitive to soy.

Click here to take advantage of this month’s promotion!