2265 North Clybourn Avenue    Chicago, IL 60614    P: 773.296.6700     F: 773.296.1131

Grapefruit Seed Extract

Posted on 02/14/2010

What Is It?

This unlikely herbal infection-fighter is synthesized from the seeds and pulp of the grapefruit. It was farmers who first used grapefruit seed Extract (GSE) to inhibit the growth of mold on their equipment; later, cosmetic companies added it to their products as a preservative.

Then, claims that GSE could fight infections in people spurred interest within the dietary supplement industry, and in the 1980s, GSE products started to appear in health-food stores. It is sometimes also called citrus seed extract.

Health Benefits

Grapefruit seed extract has been most heavily promoted as a treatment for Candida albicans, a yeast naturally present in the human body. Candida can cause complications when it grows out of control, however. GSE is particularly popular for controlling vaginal yeast infections caused by Candida, and in treating a poorly understood intestinal condition called Candida overgrowth syndrome (COS).

Some nutritionally oriented doctors continue to recommend GSE capsules, liquids, and powders for bacterial, viral, and fungal infections, including COS. However, aside from hopeful speculation, there’s no sound scientific evidence to indicate that GSE can actually eliminate any infection in human beings.

Specifically, GSE may help to:

  • Control vaginal yeast infections. One study reported that 20 women with chronic vaginal itching and other discomforts apparently due to overgrowth of the organism Candida albicans responded well to GSE douches. The study, done in Mexico, is frequently cited in the support of GSE for vaginal yeast infections. No other research on the subject appears to have been done, however.

 

  • Fight Candida overgrowth syndrome. Although no studies have proven the efficacy of GSE for this condition, it is a popular product among some alternative practitioners because of its antifungal effect.

Forms

  • powder
  • liquid
  • douche
  • capsule

Dosage Information

Special tip:

–Given its bitter taste, the liquid extract is usually mixed with a sweet fruit juice to make it more palatable.

  • For yeast infections (vaginal): When purchasing a GSE douche, follow package instructions. For capsules, liquids, or powders, take the equivalent of 130 mg GSE twice a day.
  • For Candida overgrowth syndrome: Follow package instructions.

Guidelines for Use

  • Don’t confuse GSE with grape seed extract, a powerful Antioxidant derived from red grapes.
  • GSE is occasionally sold under such names as “Standardized extract of Grapefruit,” “Grapefruit Extract,” and “Citrus Seed Extract.” Unless otherwise indicated on the label, these products are all usually made from grapefruit seeds only.

General Interaction

  • No drug or nutrient interactions have been reported for GSE. However, research is limited.
  • A number of medications should not be taken with grapefruit juice, including certain immunosuppressants, cholesterol-lowering drugs, and antihistamines. It’s not clear whether an extract of the grapefruit’s seeds and pulp pose the same risks. Consult your doctor if you have any questions.

Possible Side Effects

The risks associated with the use of GSE are probably low, but little sound research on its effects in humans have been done.

Cautions

Many of the types of infections for which GSE is recommended–vaginal yeast infections and intestinal parasites, among others–can cause potentially serious health problems if not treated properly. Consult a doctor if you suspect you have an infection.

Ailments

Yeast Infections (vaginal) – 130 mg twice a day

For product recommendations and orders click here for the Natural Apothecary or call 773-296-6700, ext. 2001.

Leave a Comment


  1. anonymous says:

    I wanted to post this on the Caprylic Acid post, but there was no section for comments. I have a few questions about Caprylic acid, if u don’t mind:

    1. For Klebsiella, what amount, length of treatment, and dosage is appropriate to treat this type of gut infection with caprylic acid?

    2. Would taking probiotics DURING treatment with Caprylic Acid be recommended? If so, how many CFUs? Would something like VSL #3 be advised?

    3. And should the probiotic be started in advance of/prior to the start of the Caprylic acid, in order to build up some good flora before potentially destroying some of it with the antibiotic properties of the caprylic acid?

    4. I imagine a higher dose of probiotics ought to be taken afterwards, right, in order to replenish/repair the gut with the good flora?

    5. Should other natural antibacterials, like oil of oregano, be used at the same time of treatment with caprylic acid, in order to prevent other possible opportunistic infections from arising?

    6. Or, would just high dose probiotics and NO caprylic acid do a better job at re-establishing normal gut flora and crowding out the bad bacteria?

    Thanks for the clarifications!!

  2. Hi anon,

    Due to FTC and FDA (DSHEA) regulations, we cannot make claims regarding specific nutrients and conditions they may treat on our website. Please feel free to contact us at apothecary@wholehealthchicago.com for further information.

Join our Newsletter

Get health recommendations, delicious and time-saving recipes, medical news, supplement reviews, birthday discounts, and more!

Health Tips

Dr. Edelberg’s Health Tips contain concise bits of advice, medical news, nutritional supplement and pharmaceutical updates, and stress relief ideas. With every Health Tip, you’ll also receive an easy, delicious, and healthful recipe.

When you sign up to receive Health Tips, you can look forward to Dr. Edelberg’s smart and very current observations arriving in your in-box weekly. They’re packed with helpful information and are often slightly irreverent. One of the most common responses to the tips is “I wish my doctor talked to me like this!”

Quick Connect

Get One Click Access to our

patient-portal

The Knowledge Base

Patient education is an integral part of our practice. Here you will find a comprehensive collection of staff articles, descriptions of therapies and nutritional supplements, information addressing your health concerns, and the latest research on nutritional supplements and alternative therapies.

Telemedicine – Now Available at WholeHealth Chicago

In order to maintain your continuity of care, WholeHealth Chicago now offers telemedicine appointments with most of our practitioners. During a telemedicine visit, you and your healthcare provider can review medical history, discuss symptoms, arrange for prescriptions, and more. When necessary, labs and diagnostic imaging can be ordered from a facility near your home, and our Natural Apothecary can ship supplements quickly to your door.

Please contact Patient Services for details and scheduling a telemedicine appointment, or to change a regular appointment to telemedicine by calling 773-296-6700.

We’re looking forward to meeting with you in our virtual consultation room soon.

DIAGNOSE-IT-YOURSELF: COVID-19

Far and away, the commonest phone call/e mail I receive asks about COVID-19 diagnosis.
Just print this out, tape it on your refrigerator door, and stay calm.

ALLERGIES

• Runny nose
• Sneezing
• Red, swollen eyes
• Itchy eyes and nose
• Tickly throat
• No fever

COLD
• Runny nose
• Sneezing
• Sore throat
• Mild muscle aches
• Mild dry cough
• Rarely a low fever

STREP THROAT
• Painful sore throat
• Hurts to swallow
• Swollen glands in neck
• Fever

FLU (Standard seasonal flu)
• Fever
• Dry cough (no mucus)
• Sudden onset over few hours
• Headache
• Sore throat
• Fatigue, sometimes quite severe
• Muscle aches, sometimes quite severe
• Rarely, diarrhea

CORONAVIRUS-COVID 19
• Shortness of breath
• Fever (usually above 100 degrees)
• Dry cough (no mucus)
• Slow onset (2-14 days)
• Mild muscle aches
• Mild fatigue
• Mild sneezing

Recent Health Tips

  • The Flu Shot: Now More Important Than Ever

    When it comes to the flu shot, I take a far more conventional approach than many WholeHealth Chicago patients expect of a doctor who considers himself alternative/integrative. It’s also worth noting that after reviewing some of the online advice warning people away from the flu shot, it’s my sense that this is frequently followed by “…and this is my product you can buy instead.” So Read More

  • Lyme Disease In Your Nervous System: Three Cases

    “Why am I limiting this to only three cases?” I wondered. Physicians who treat Lyme, like our group at WholeHealth Chicago where we see a lot of Lyme disease patients, would tell you there are so many manifestations of Lyme when it invades the nervous system that I really should list as many as possible. But to keep this Health Tip manageable, we’ll keep it Read More

  • The Heartburn That Wouldn’t Quit

    Dierdre had written “I want to get off my heartburn medicine” on her WholeHealth Chicago intake form. This, by the way, was a tele-med appointment. I’ve actually never met her in person. We changed Dierdre’s name to respect her privacy, but her story is worth sharing. Dierdre was in her 30s and had been working at home at one of the many jobs people can Read More

Join our Discount Program

Member benefits include 10% off all your purchases. Low, one-time membership fee of $25 ($35 for family).

MORE INFORMATION

Join our Newsletter

Get health recommendations, recipes, medical news, supplement reviews, birthday discounts, and more!