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Q&A: SAMe or St. John’s Wort?

Q.   A friend of mine just tried SAMe for depression and is having a very positive experience with it in a very short time. Can you tell me why in The Triple Whammy Cure you emphasize St. John’s Wort as a natural antidepressant instead?

A. As part of my response to this excellent question, I’m going to devote a future health tip to a more comprehensive review of  SAMe, which I do like as a safe and effective antidepressant. In the book I emphasize St. John’s wort for several reasons:

  • St. John’s wort has more published clinical studies than SAMe, a relative newcomer on the scene.
  • There’s a cost factor. SAMe is simply more expensive than St. John’s wort.
  • Finally, dosing is mildly inconvenient with SAMe. You must take it on an empty stomach, either one hour before eating or two hours after. As a major proponent of keeping things simple, I like the easier scheduling with St. John’s wort.

With that said, St. John’s wort doesn’t work for everyone. If you’re among this group and you’re reluctant to move to a prescription antidepressant, or you simply want to try a faster-acting natural antidepressant, SAMe might be just the ticket. Read more about it by clicking here.


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**Winter Solstice Celebration: An evening of Acupuncture and Shamanic Healing
Tuesday, December 17, 5:45–7:30pm
Hosted by Katie Oberlin, HTCP and Mari Stecker, LAc

Course Fee: $75.00

Take a break from the hustle and bustle of the holiday season to enter the stillpoint of the Winter Solstice, reflect on the lessons of 2019, and set intentions for the new year. This will be an evening of individual and group healing, ceremony, and celebration. More →

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